New research indicates that people who stop using new GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight far faster than those who halt traditional diet and exercise plans.
Published data in a leading medical journal points out that while overweight people often shed substantial amounts of their total mass while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"People purchasing these medications need to be informed of the risk of rapid weight regain when the medication is stopped," cautioned expert Dr. Susan Jebb.
Such speed of recovery suggests a reversion to original mass within about one and a half years.
Comparing Treatments
The study, which examined 37 of trials involving thousands of patients, compared the effects of these new drugs with older methods.
Researchers note that individuals who lose weight through dieting usually have a more gradual weight regain—around 100 grams monthly—after stopping.
The Reason for the Fast Regain
Nutrition scientists propose the way of the injections accounts for the accelerated regain.
GLP-1 drugs mimic a body's own chemical called GLP-1, which helps regulate appetite.
"Long-term administration of the hormone concentrations several times higher than the body's typical production could lead to the body to produce less of its own natural hormone, and may also reduce responsiveness to its actions," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement results in appetite is uncontrolled, making excessive eating much more probable."
A Lifelong Issue?
Medical guidelines advise the injections for people with weight-linked health risks, alongside recommended lifestyle changes.
Professionals say that, due to the likelihood of weight regain, the treatment might need to be ongoing.
This view is supported by pharmaceutical companies, who say that the findings "underscore the long-term nature of obesity," comparing it to managing diseases like diabetes.
User Accounts
Users who have stopped the medication explain a powerful return of appetite.
"It felt as if a switch activating and you're instantly ravenous," described one woman.
This challenge is worsened if individuals have not developed permanent dietary or behavioural changes during treatment.
Widespread Interest
Survey data show that a significant number of adults in the UK have tried weight-loss jabs in the past year, with interest continuing to grow.
- Use is greater among women compared to men.
- The middle-aged age group shows the highest level of interest.
- A large proportion access the medications through private prescriptions rather than the NHS.
In conclusion, experts caution that while GLP-1 drugs are potent agents for shedding pounds, they are not a permanent solution and lasting health benefits hinges on ongoing lifestyle support.
